Polynucleotides (PNs) are one of the most revolutionary developments in regenerative aesthetic medicine. These treatments work at a cellular level to repair tissue, enhance skin quality, and restore youthful function in both the face and body.
PNs are derived from highly purified DNA fragments sourced from salmon or trout. These DNA molecules are biocompatible and safe, making them incredibly effective at stimulating repair within damaged or ageing skin.
When injected, PNs work by stimulating fibroblasts, supporting healthy cell turnover, improving elasticity, boosting collagen production, and deeply hydrating the skin.
Polynucleotides have been used in medical practice for over 35 years, especially in wound healing. Early clinical applications included treatment of diabetic ulcers and slow-healing surgical wounds.
At Luxe Line Clinic, we use the Nucleofill® range, one of the most advanced and clinically robust PN systems available.
Nuclofill® Soft Plus – Gentle Eye & Delicate Skin Rejuvenation
Nuclofill® Medium – Universal Skin Rejuvenation & Texture Renewal
Nuclofill® Strong – Deep Regeneration & Firming
For best results protocol involves 4 sessions, 2-3 weeks apart from each other.
Follow up maintenance one session every 4-6 months.
Polynucleotides can significantly improve:
Results develop progressively as the skin undergoes internal regeneration.
Nucleofill® is an advanced injectable treatment made from polynucleotides (PNs), which are purified DNA fish fragments. It works at a cellular level to stimulate skin repair, improve hydration, and enhance overall skin quality without adding volume.
Nucleofill® stimulates fibroblasts to increase collagen production, improves skin elasticity, supports tissue regeneration, and enhances deep hydration. This results in healthier, stronger, and more resilient skin over time.
Nucleofill® can be used on:
Your practitioner will select the most appropriate Nucleofill® product based on the treatment area.
No. Nucleofill® is not a dermal filler. It does not add volume or alter facial structure. Instead, it improves skin quality by stimulating natural regeneration within the tissue.
Most clients require a course of 4 sessions, spaced 2-4 weeks apart, depending on skin condition, age, and treatment area. Maintenance treatments are typically recommended every 6-9 months.
Some improvement may be visible after the first session, but results develop gradually. The full regenerative effect is usually noticeable around 8-12 weeks after completing the treatment course.
Results typically last 6-9 months. As Nucleofill® stimulates natural skin repair, improvements in skin quality may continue even after the product has been absorbed.
Discomfort is minimal. A fine needle is used, and a numbing cream can be applied before treatment to ensure comfort. Most clients describe the sensation as mild and well tolerated.
Downtime is minimal. You may experience:
These usually resolve within 24–72 hours.
Yes. Nucleofill® is clinically tested, CE-marked, and widely used in aesthetic medicine. It has an excellent safety profile when administered by a qualified medical professional.
Side effects are usually mild and temporary, including redness, swelling, tenderness, or bruising at the injection sites. Serious complications are extremely rare.
Nucleofill® may not be suitable if you are:
A full medical consultation is required before treatment.
Yes. Nucleofill® pairs well with treatments such as microneedling, skin boosters, and energy-based devices. Your practitioner will advise on correct timing and sequencing.
After treatment, you should:
Full aftercare advice will be provided after your appointment.
Yes. Nucleofill® is suitable for both men and women looking to improve skin quality, hydration, and signs of ageing in a natural way.
Unlike traditional skin boosters, Nucleofill® focuses on cellular regeneration rather than hydration alone, making it ideal for skin that is thin, damaged, or showing advanced signs of ageing.